Oooooh kay. Let's see, theories...
The last forums said "A slice of the college life Virtual novel" up in the header. Since a basic premise is usually the first thing brought up, it's probably going to stay in a college setting.
The devs probably don't want to be considered a katawa klone, so there's a good chance that the setting will be somewhere other than Japan. North America, maybe? KS+ on the other hand, attempted to be a sequel/side story, so they're probably going to stick with as similar a setting to KS as possible.
The relationships in the game will progress at different paces compared to KS, probably with longer periods of time being depicted in the game. Going "one step further" could mean moving in with path girls, meeting parents, and hell, maybe even going as far as proposing marriage during the course of the story.